TEL AVIV/DUBAI/WASHINGTON, June 13 (Reuters) – Iran launched retaliatory airstrikes at Israel on Friday night, with explosions heard in Jerusalem and Tel Aviv, the country’s two biggest cities, following Israel’s biggest-ever military strike against its longstanding enemy.

Air raid sirens sounded across Israel as authorities urged the public to take shelter. Missiles were seen over Tel Aviv’s skyline, with the military saying Iran had fired two salvos.

The U.S. military has helped shoot down Iranian missiles that were headed toward Israel, two U.S. officials said on Friday.

In the Tel Aviv area, Israel’s ambulance service said five people were treated for shrapnel injuries. Live footage of Tel Aviv showed what appeared to be a missile hitting an urban area. A critically injured woman was admitted to Beilinson Hospital in nearby Petah Tikva, a hospital spokesperson said.

The unprecedented Israeli strikes on Iran and the subsequent Iranian retaliation raised concerns about a broader regional conflagration, although Iran’s allies Hamas in Gaza and Hezbollah in Lebanon have been decimated by Israel.

Iran’s state news agency IRNA said Tehran launched hundreds of ballistic missiles at Israel after Israel blasted Iran’s huge Natanz underground nuclear site and killed its top military commanders. Israel’s military said Iran fired fewer than 100 missiles and most were intercepted or fell short.

Iran’s Supreme Leader Ayatollah Ali Khamenei accused Israel of having initiated a war. A senior Iranian official said nowhere in Israel would be safe and revenge would be painful.

Smoke rises after a missile attack in Tel Aviv, Israel, Friday, June 13, 2025. (AP Photo/Leo Correa)
Smoke rises after a missile attack in Tel Aviv, Israel, Friday, June 13, 2025. (AP Photo/Leo Correa)

Israel’s operation “will continue for as many days as it takes to remove this threat,” Israeli Prime Minister Benjamin Netanyahu said in a TV address.

Netanyahu, who for decades has raised the alarm about Iran’s nuclear programme, said he authorised the air assault in an effort to prevent Iran from building nuclear weapons. Israel and its Western allies have said this is Tehran’s objective but Iran has denied it.

In a video issued by his office, Netanyahu appealed to the Iranian people to stand up against their leaders. “I am with you, the Israeli people are with you,” he said.

“Generations from now, history will record our generation stood its ground, acted in time and secured our common future.”

Iran has long insisted its nuclear programme is for civilian purposes only. The U.N. nuclear watchdog concluded this week that it was in violation of its obligations under the global non-proliferation treaty.

U.S. President Donald Trump said it was not too late for Tehran to halt the Israeli bombing campaign by reaching a deal on its nuclear programme.

Tehran had been engaged in talks with the Trump administration on a deal to curb its nuclear programme to replace one that Trump abandoned in 2018. Tehran had rejected the last U.S. offer.

A man walks at the scene of an explosion in a residence compound in northern Tehran, Iran, Friday, June 13, 2025. (AP Photo/Vahid Salemi)
A man walks at the scene of an explosion in a residence compound in northern Tehran, Iran, Friday, June 13, 2025. (AP Photo/Vahid Salemi)

ATTACKS ON IRAN

Iranian media showed images of destroyed apartment blocks in Iran, and said nearly 80 civilians were killed in attacks that targeted nuclear scientists in their beds and wounded more than 300 people.

Israel’s military said it was striking Iranian missile and drone launching sites, and had struck another nuclear site in Isfahan.

An Israeli military spokesperson denied Iranian media reports that an Israeli fighter jet was downed with a pilot detained.

In a phone interview with Reuters, Trump said nuclear talks between Tehran and the United States, scheduled for Sunday, were still on the agenda though he was not sure if they would take place.

“We knew everything,” Trump said of the Israeli attack plans.

“I tried to save Iran humiliation and death. I tried to save them very hard because I would have loved to have seen a deal worked out,” Trump said. “They can still work out a deal, however, it’s not too late.”

Israeli National Security Adviser Tzachi Hanegbi said military action by itself would not destroy Iran’s nuclear programme, but could “create the conditions for a long-term deal, led by the United States” to get rid of it.

Smoke rises up after an explosion in Tehran, Iran, Friday, June 13, 2025. (AP Photo/Vahid Salemi)
Smoke rises up after an explosion in Tehran, Iran, Friday, June 13, 2025. (AP Photo/Vahid Salemi)

DECAPITATION

Two regional sources said at least 20 Iranian military commanders were killed, a stunning decapitation reminiscent of Israeli attacks that swiftly wiped out the leadership of Lebanon’s once-feared Hezbollah militia last year. Iran also said six of its top nuclear scientists had been killed.

Among the generals killed on Friday were the armed forces chief of staff, Major General Mohammad Bagheri, and the Revolutionary Guards chief, Hossein Salami.

Major General Mohammad Pakpour, swiftly promoted to replace Salami as Guards commander, vowed retaliation in a letter to the Supreme Leader read on state television: “The gates of hell will open to the child-killing regime.”

Iranians described an atmosphere of fear and anger, with some people rushing to change money and others seeking a way out of the country to safety.

“People on my street rushed out of their homes in panic. We were all terrified,” said Marziyeh, 39, who was awakened by a blast in Natanz.

While some Iranians quietly hoped the attack would lead to changes in Iran’s hardline clerical leadership, others vowed to rally behind the authorities.

“I will fight and die for our right to a nuclear programme. Israel and its ally America cannot take it away from us with these attacks,” said Ali, a member of the pro-government Basij militia in Qom.

Iran’s ability to retaliate with weapons fired by its regional proxies has been sharply degraded over the past year, with the downfall of its ally Bashar al-Assad in Syria and the decimation of Hezbollah in Lebanon and Hamas in Gaza.

Israel said a missile fired from Yemen – whose Houthi militia are Iran-aligned – had landed in Hebron in the occupied West Bank. The Palestinian Red Crescent said three Palestinian children were wounded by shrapnel there.

Iranian protesters hold up Iranian and Palestinian flags in an anti-Israeli gathering in Tehran, Iran, Friday, June 13, 2025. (AP Photo/Vahid Salemi)
Iranian protesters hold up Iranian and Palestinian flags in an anti-Israeli gathering in Tehran, Iran, Friday, June 13, 2025. (AP Photo/Vahid Salemi)

‘COWARDLY’

Israel said that Iran launched around 100 drones towards Israeli territory earlier on Friday, but Iran denied this and there were no reports of drones reaching Israeli targets.

The United Nations Security Council was due to meet on Friday at Tehran’s request. Iran said in a letter to the council that it would respond decisively and proportionally to Israel’s “unlawful” and “cowardly” acts.

The price of crude LCOc1 leaped on fears of wider retaliatory attacks across a major oil-producing region, although there were no reports that oil production or storage was damaged. OPEC said the escalation did not justify any immediate changes to oil supply.

An Israeli security source said Mossad commandos had been operating deep inside the Islamic Republic before the attack, and the Israeli spy agency and military had mounted a series of covert operations against Iran’s strategic missile array.

Israel also established an attack-drone base near Tehran, the source added. The military said it had bombarded Iran’s air defences, destroying “dozens of radars and surface-to-air missile launchers”.

Israeli officials said it may be some time before the extent of damage to the underground nuclear site at Natanz is clear. Western countries have long said Iran refined uranium there to levels suitable for a bomb rather than civilian use.

Later on Friday, Iranian media reported explosions on the northern and southern outskirts of Tehran and at Fordow, near the holy city of Qom, a second nuclear site that was spared in the first wave of attacks.

EXPLAINER – What’s behind Iran’s long tussle with the United States? Read full story

EXPLAINER-Where are Iran’s main nuclear sites and what does it use them for? Read full story

EXPLAINER-How Iran’s network of Middle East power faded Read full story

World reacts to Israeli strike on Iran over nuclear programme Read full story

ANALYSIS-After years of waiting, Israel’s Netanyahu finally makes his move on Iran Read full story

(Reporting by Reuters; Writing by Peter Graff, Michael Georgy and Howard Goller; Editing by Raju Gopalakrishnan, Kevin Liffey, Aidan Lewis and Cynthia Osterman)

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